ANALYSIS OF STATUS OF METHYLATION OF THE TUMOR SUPPRESSOR GENE RAR?2 AS A MARKER OF DIAGNOSTICS AND EFFECTIVENESS OF TREATMENT OF BREAST CANCER
Kadyrova Diloram Abdullaevna, Isanbaeva Landysh Mukhamedzakievna
A. S. Sadykov Institute of Bioorganic Chemistry of the Academy of Sciences of the Republic of Uzbekistan in Tashkent
Tashkent Institute of Postgraduate Medical Education
Abstract. Epigenetic inactivation of tumor suppressor genes conditioned by hypermethylation of the promoter region is the same characteristic feature of human tumors as genetic disorders, and serves as an alternative mechanism for the loss of the function of suppressor genes. The promoter region of the RAR?2 suppressor gene is analyzed in a normal state and in breast cancer by the methylation-sensitive polymerase chain reaction method. Methylation of CpG dinucleotides in the promoter region of the RAR?2 gene is shown. Abnormal methylation of the promoter region of the RAR?2 gene can be used as a marker for early diagnostics and monitoring of effectiveness of treatment of patients with breast cancer.
Key words and phrases: рак молочной железы, ген-супрессор RAR?2, метилирование CpG-динуклеотидов, маркеры ранней диагностики, breast cancer, RAR?2 suppressor gene, methylation of CpG dinucleotides, markers of early diagnosis
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