CONTRIBUTION OF NUCLEUS AND SUBSTITUENTS OF SYNTHESIZED DERIVATIVES OF 2'-SUBSTITUTED CHALCONES IN ACTIVITY OF SUBSTANCES WITH PROVISION FOR THEIR POSITIONS
Ismailova Gulzira Orynbaevna, Yuldashev Nasirdzhan Mukhamedzhanovich, Rakhimova Gulnora Rakhimovna, Kharisova Indira Iskakovna
Tashkent Pediatric Medical Institute, The Republic of Uzbekistan
Tashkent Pharmaceutical Institute, The Republic of Uzbekistan
Abstract. The article deals with the spectral analysis "structure of substance - biological activity" of synthesized derivatives of 2'-substituted chalcones on the basis of the modern system "Prediction of Activity Spectra for Substances". The given structures are proved by the X-ray analysis, their physical and thermodynamic properties are examined. The authors focus on biological activity of substances in connection with their structure in terms of contribution of the invariable part - the nucleus - and substituents with provision for their positions.
Key words and phrases: 2?-замещенные халконы, ядро, функциональные группы, рентгеноструктурный анализ, структура, биологическая активность, 2'-substituted chalcones, nucleus, functional groups, X-ray analysis, structure, biological activity
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