OLIGOESTERS INFLUENCE ON WARM-BLOODED ANIMALS’ METABOLIC STATUS UNDER SUBACUTE EXPERIMENT CONDITIONS
Bagmut Irina Yur'evna, Zaitseva Ol'ga Vasil'evna, Zhukov Viktor Ivanovich, Knigavko Vladimir Gilyarievich
Kharkiv Medical Academy of Post-Graduate Education, Ukraine
Kharkiv National Medical University, Ukraine
Abstract. The influence of oligoesters new group on liver metabolic status and also some indicators of energy and carbohydrate metabolism were researched under the conditions of subacute toxicological experiment. The uncoupling of tissue respiration and oxidative phosphorylation against the background of adenosine triphosphate production reducing, and also the derangements of carbohydrate, protein, lipidic metabolisms and the significant inhibition of xenobiotics detoxication processes are determined.
Key words and phrases: ксенобиотики, метаболический статус, тканевое дыхание, энергетический и углеводный обмен, белые крысы, подострый токсикологический эксперимент, xenobiotics, metabolic status, tissue respiration, energy and carbohydrate metabolism, albino rats, subacute to
Open the whole article in PDF format. Free PDF-files viewer can be downloaded here.
References:
Vladimirov Yu. A., Archakov A. I. Perekisnoe okislenie lipidov v biologicheskikh membranakh. M.: Nauka, 1972. 252 s.
Zhukov V. I., Zaitseva O. V., Piven' V. I., Sidorenko N. A. i dr. Ftoridy: biologicheskaya rol' i mekhanizm deistviya. Belgorod: Belvitaminy, 2006. 220 s.
Zhukov V. I., Popova L. D., Zaitseva O. V., Kratenko R. I. i dr. Prostye i makrotsiklicheskie efiry: nauchnye osnovy okhrany vodnykh ob"ektov. Khar'kov: Tornado, 2000. 438 s.
Laboratornye metody issledovaniya v klinike: spravochnik / pod red. prof. V. V. Menshikova. M.: Meditsina, 1987. 368 s.
Meshkova N. P., Severin S. E. Praktikum po biokhimii. M.: MGU, 1979. 428 s.
Pokrovskii A. A. Biokhimicheskie metody issledovaniya v klinike. M.: Meditsina, 1969. 652 s.
Shcherban' N. G., Zhukov V. I., Myasoedov V. V., Kapustnik V. A. Biokhimicheskie mekhanizmy radiomimeticheskikh effektov poverkhnostno-aktivnykh veshchestv. Khar'kov: Raritety Ukrainy, 2012. 120 s.
Asaoka K., Takahashi K. An Enzymatic Assay of Reduced Glutathione Using Glutathione S-aryltransferase with O-dinitrobenzene as a Substrate // Journal of Biochemistry. 1981. Vol. 90. № 5. R. 1237-1242.
European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes [Elektronnyi resurs]. URL: http://conventions.coe.int/Treaty/en/Treaties/Html/123.htm (data obrashcheniya: 04.12.2013).